Closed-loop digital therapeutics

Elevating brain region activation

Brainmarc’s closed-loop digital therapeutic platform shows dramatic clinical outcomes which correlate with the amount of effective recruitment of attention, and cause significant increases in the activation of brain regions involved in therapy processes. This leads to the formation of compensatory connections to overcome reduced activity in these regions. Increases in attention-driven activation result in greater brain plasticity, which may underlie effective outcomes across a wide variety of conditions.

Stroke therapy

Positive clinical outcomes have been shown to correlate with effective recruitment of attention during therapeutic activities. The performance biomarker may provide real-time, online feedback about user engagement during physical and stroke therapy sessions. This feedback, when used to adjust difficulty levels and strategies during the session, can dramatically improve the clinical outcome of the session. The value of Brainmarc’s performance monitor for therapy guidance has been demonstrated in several clinical trials on a wide range of subjects (post-stroke and control) (Bartur et al, 2015).


The performance biomarker may provide real-time, online feedback regarding the effectiveness of electromagnetic (TMS) and other treatments used for depression. As the dynamic biomarker can predict the clinical dynamics of depression over the subsequent weeks, it can provide an early indication of treatment efficacy or can alert the patient and/or caregiver about impending deterioration.



The performance biomarker may provide real-time, online evaluation of current ADHD status, as well as predict the clinical dynamics of the disorder over the coming hours. As such, the bei™ and bes™ based platform can serve as an important adjunct to corrective teaching sessions, optimize task scheduling, and support evidence-based decisions regarding the need for, or level of, pharmaceutical ADHD treatment.

Reference papers

Post Stroke rehabilitation

An EEG tool for monitoring patient engagement during stroke rehabilitation – A feasibility study

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Electrophysiological marker for depression treatment

A pilot study of possible easy-to-use electrophysiological index for early detection of anti-depressive treatment non-response

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ADHD attention Monitoring

Monitoring attention in ADHD with an easy-to-use electrophysiological index

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